The letter addressed to the Chancellor outlines strategies to drive economic growth by enhancing investment in innovative science and technology companies in the UK. It highlights the UK’s position as a leading innovation hub, with over 750 venture-backed firms generating significant revenue. The Council for Science and Technology (CST) emphasizes the need to unlock £4.6 trillion in private and public assets to support scaling challenges faced by these companies. Recommendations include accelerating pension fund reforms, improving connections between private and public markets, developing specialized skills, leveraging digital infrastructure, and promoting investment opportunities to strengthen the UK’s innovation economy.